What’s the difference between GLP-1 and SGLT2 medications?
Great question! Both GLP-1 and SGLT2 medications are used to treat type 2 diabetes, but they work in different ways.
GLP-1 medications (like Ozempic or Trulicity) are usually given as weekly injections. They help your body release more insulin when you eat, slow down how quickly food leaves your stomach, and can help you feel full longer—which often leads to some weight loss. Many people find these medications helpful for both blood sugar control and weight management, but they can sometimes cause nausea or stomach upset.
SGLT2 medications (like Jardiance or Farxiga) are taken as daily pills. They work by helping your kidneys get rid of extra sugar through your urine. This not only lowers blood sugar, but can also help protect your heart and kidneys. The main side effects are needing to pee more often and, in some cases, a higher risk of urinary tract infections.

GLP-1s are mostly injections, help with blood sugar and weight, but can cause some stomach issues. SGLT2s are pills, help your body flush out sugar, and are good for heart and kidney health, but can cause more frequent urination.
Your doctor will help you choose the best option for your needs. If you want to learn more, check out this research: