Weight-loss drugs deliver impressive results - but what happens when you stop?
A major new BMJ analysis shows that most people regain weight rapidly after discontinuing weight-loss medications, with benefits to blood sugar, cholesterol, and blood pressure fading within a year. Even more striking: weight regain is faster after stopping drugs like semaglutide and tirzepatide than after lifestyle programmes, despite greater initial weight loss.
As prescriptions soar, this evidence reframes obesity as a chronic condition that may require long-term treatment, not short-term fixes. A must-read for clinicians, policymakers, and anyone thinking about what “success” in weight loss really means.
https://www.bmj.com/content/392/bmj-2025-085304
4 Views
